Neutralizing the Threat: Pan-Ebolavirus Antibodies Close the Loop
نویسندگان
چکیده
منابع مشابه
Neutralizing the Threat: Pan-Ebolavirus Antibodies Close the Loop.
The glycoprotein (GP) of ebolaviruses participates in a critical membrane fusion process to establish infection of a cell and therefore, represents an important target of both vaccines and antivirals. The latest reports on pan-ebolavirus monoclonal antibodies in small animal models may offer promising outcomes and insight into how best to target the GP in vaccine and antiviral discovery.
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UNLABELLED The unprecedented 2014-2015 Ebola virus disease (EVD) outbreak in West Africa has highlighted the need for effective therapeutics against filoviruses. Monoclonal antibody (MAb) cocktails have shown great potential as EVD therapeutics; however, the existing protective MAbs are virus species specific. Here we report the development of pan-ebolavirus and pan-filovirus antibodies generat...
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During the latest outbreak of Ebola virus disease in West Africa, monoclonal antibody therapy (e.g., ZMapp) was utilized to treat patients. However, due to the antigenic differences among the five ebolavirus species, the current therapeutic monoclonal antibodies are only effective against viruses of the species Zaire ebolavirus. Although this particular species has indeed caused the majority of...
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ژورنال
عنوان ژورنال: Trends in Molecular Medicine
سال: 2017
ISSN: 1471-4914
DOI: 10.1016/j.molmed.2017.06.008